# OnCo record idea-bio2-implanted-ultrasound-repeat-dosing (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-implanted-ultrasound-repeat-dosing/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-implanted-ultrasound-repeat-dosing" ;
  schema:name "A skull ultrasound implant that opens the barrier at every cycle"@en ;
  schema:description "A small ultrasound device implanted in the skull can be switched on at each chemotherapy visit to briefly open the brain barrier, letting drugs in every cycle."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-implanted-ultrasound-repeat-dosing/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa043330> ;
  onco:related <https://onco.cc/ideas/idea-fus-plus-adc-glioma/> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/> ;
  onco:technologies <https://onco.cc/technologies/bbb-focused-ultrasound/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/temozolomide/> ;
  onco:terms <https://onco.cc/terms/blood-brain-barrier/> ;
  onco:trials <https://onco.cc/trials/nct05902169/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-carboplatin-glioblastoma-neuro-oncol-2003/>, <https://onco.cc/key-papers/paper-carboplatin-glioblastoma-neuro-oncol-2015/>, <https://onco.cc/key-papers/paper-carboplatin-glioblastoma-eur-j-cancer-2017/> .