# OnCo record idea-bio2-intraventricular-car-t (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-intraventricular-car-t/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-intraventricular-car-t" ;
  schema:name "Deliver CAR-T cells straight into the fluid around the brain"@en ;
  schema:description "Cancer spreading along the linings of the brain has no treatment that reliably controls it. Injecting engineered immune cells directly into the brain fluid, through a small reservoir, reaches it."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-intraventricular-car-t/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa043330> ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/glioblastoma/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/glioma-car-t/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/b7h3/> ;
  onco:institutions <https://onco.cc/institutions/city-of-hope/> ;
  onco:terms <https://onco.cc/terms/her2-brain-metastases/>, <https://onco.cc/terms/crs/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-metastasis-biology/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-slamon-her2-breast-ovarian-science-1989/>, <https://onco.cc/key-papers/paper-yarden-sliwkowski-erbb-network-nrmcb-2001/> .