# OnCo record idea-bio2-let-rbe-ab-selects-protons (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-let-rbe-ab-selects-protons/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-let-rbe-ab-selects-protons" ;
  schema:name "Use LET, RBE and alpha/beta to decide when protons beat IMRT"@en ;
  schema:description "Protons cost more than shaped X-ray beams. They are worth it when the extra punch where the beam stops, and the missing exit dose, widen the gap between killing the tumour and harming late-reacting tissue: an alpha/beta and RBE question, not a machine question."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-let-rbe-ab-selects-protons/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.ijrobp.2014.07.001>, <https://clinicaltrials.gov/study/NCT01617161>, <https://clinicaltrials.gov/study/NCT02603341> ;
  onco:tag "radiation-wave5" ;
  onco:related <https://onco.cc/ideas/idea-fund-proton-coverage-with-evidence/>, <https://onco.cc/pairings/proton-vs-imrt/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/nsclc/> ;
  onco:sections <https://onco.cc/fronts/radiation/> ;
  onco:technologies <https://onco.cc/technologies/proton-therapy/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/technologies/carbon-ion/>, <https://onco.cc/technologies/linear-quadratic-model/>, <https://onco.cc/technologies/intensity-modulated-proton-therapy/> ;
  onco:terms <https://onco.cc/terms/linear-energy-transfer/>, <https://onco.cc/terms/relative-biological-effectiveness/>, <https://onco.cc/terms/alpha-beta-ratio/>, <https://onco.cc/terms/bragg-peak/>, <https://onco.cc/terms/biologically-effective-dose/> ;
  onco:trials <https://onco.cc/trials/partiqol/>, <https://onco.cc/trials/radcomp/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-surgery-radiation-innovation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-paganetti-proton-rbe-ijrobp-2014/> .