# OnCo record idea-bio2-liver-niche-kupffer-reprogramming (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-liver-niche-kupffer-reprogramming/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-liver-niche-kupffer-reprogramming" ;
  schema:name "Reprogramme the liver's own immune cells to refuse metastases"@en ;
  schema:description "The liver is where bowel cancer most often spreads. Drugs delivered straight into the liver's blood supply could retrain its resident immune cells to reject arriving cancer cells."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-liver-niche-kupffer-reprogramming/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1002/cam4.2474> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/sting-agonist/>, <https://onco.cc/technologies/radioembolisation-tare/> ;
  onco:terms <https://onco.cc/terms/oligometastatic/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-metastasis-biology/>, <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dillekas-cancer-med/> .