# OnCo record idea-bio2-matrix-stiffness-prevention (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-matrix-stiffness-prevention/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-matrix-stiffness-prevention" ;
  schema:name "Soften the tissue that new metastases need in order to grow"@en ;
  schema:description "Cancer cells need stiff, cross-linked tissue scaffolding to settle and grow in a new organ. Blocking the enzymes that build it may stop new colonies taking hold."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-matrix-stiffness-prevention/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1002/cam4.2474> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:pathways <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/emt/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/> ;
  onco:people <https://onco.cc/people/erik-sahai/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-metastasis-biology/>, <https://onco.cc/bottlenecks/b-negative-results/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dillekas-cancer-med/> .