# OnCo record idea-bio2-mechanism-defined-baskets (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-mechanism-defined-baskets/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-mechanism-defined-baskets" ;
  schema:name "Group trials by broken mechanism, not by organ or single mutation"@en ;
  schema:description "Rare cancers often share a broken cellular machine even when they arise in different organs. Grouping patients by that shared fault makes trials possible."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-mechanism-defined-baskets/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.ejca.2011.08.008> ;
  onco:related <https://onco.cc/ideas/idea-mtap-prmt5-mesothelioma/>, <https://onco.cc/collections/depmap/>, <https://onco.cc/collections/oncokb/> ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/ovarian/> ;
  onco:technologies <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/epigenetic-drugs/> ;
  onco:targets <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/idh/>, <https://onco.cc/targets/kmt2a/> ;
  onco:terms <https://onco.cc/terms/synthetic-lethality/>, <https://onco.cc/terms/tumour-agnostic/>, <https://onco.cc/terms/gene-fusion/> ;
  onco:trials <https://onco.cc/trials/pediatric-match/>, <https://onco.cc/trials/nct03213665/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-rare-cancers/>, <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-gatta-eur-j-cancer/>, <https://onco.cc/key-papers/paper-ezh2-ovarian-mol-cancer-ther-2018/>, <https://onco.cc/key-papers/paper-ezh2-sarcoma-bmc-med-2011/>, <https://onco.cc/key-papers/paper-ezh2-sarcoma-biochem-pharmacol-2023/> .