# OnCo record idea-bio2-mrd-guided-endocrine-duration (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-mrd-guided-endocrine-duration/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-mrd-guided-endocrine-duration" ;
  schema:name "Use residual disease tests to decide who needs ten years of hormone therapy"@en ;
  schema:description "Extended hormone therapy after breast cancer prevents late recurrence in a minority of women while imposing joint pain, bone loss and sexual side-effects on everyone for a decade. A sensitive residual disease blood test at year five, repeated annually, could show who can safely stop."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-mrd-guided-endocrine-duration/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2200075> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/endocrine-therapy/> ;
  onco:terms <https://onco.cc/terms/late-recurrence/>, <https://onco.cc/terms/mrd/> ;
  onco:trials <https://onco.cc/trials/soft-text/>, <https://onco.cc/trials/monarche/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dormancy-mrd/>, <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-survivorship/> .