# OnCo record idea-bio2-myeloid-engager-bispecific (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-myeloid-engager-bispecific/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-myeloid-engager-bispecific" ;
  schema:name "Bispecific antibodies that engage macrophages instead of T cells"@en ;
  schema:description "Drugs that grab T cells and drag them onto tumours work well in blood cancers. The same trick aimed at tumour-eating cells might work where T cells are absent."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-myeloid-engager-bispecific/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:technologies <https://onco.cc/technologies/bispecific-antibody/>, <https://onco.cc/technologies/car-nk-macrophage/> ;
  onco:targets <https://onco.cc/targets/cd47/>, <https://onco.cc/targets/her2/>, <https://onco.cc/targets/trop2/> ;
  onco:drugs <https://onco.cc/drugs/magrolimab/> ;
  onco:terms <https://onco.cc/terms/fc-effector/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/> .