# OnCo record idea-bio2-neoadjuvant-biomarker-engine (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-neoadjuvant-biomarker-engine/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-neoadjuvant-biomarker-engine" ;
  schema:name "Use pre-surgery immunotherapy windows as the field's biomarker engine"@en ;
  schema:description "Giving immunotherapy for a few weeks before surgery produces a tumour sample that shows exactly what the drug did. That is the fastest way to learn who responds."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-neoadjuvant-biomarker-engine/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/urothelial/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/single-cell-spatial/>, <https://onco.cc/technologies/rna-seq/> ;
  onco:terms <https://onco.cc/terms/major-pathological-response/>, <https://onco.cc/terms/pcr/>, <https://onco.cc/terms/neoadjuvant-adjuvant/> ;
  onco:trials <https://onco.cc/trials/niche-2/>, <https://onco.cc/trials/nadina/>, <https://onco.cc/trials/checkmate-816/> ;
  onco:people <https://onco.cc/people/myriam-chalabi/>, <https://onco.cc/people/christian-blank/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-immunotherapy-response/>, <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-negative-results/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/> .