# OnCo record idea-bio2-oncolytic-regulated-il12 (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-oncolytic-regulated-il12/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-oncolytic-regulated-il12" ;
  schema:name "Oncolytic viruses that make interleukin-12 only inside the tumour"@en ;
  schema:description "Interleukin-12 is an immune-stimulating cytokine that caused severe toxicity when injected into the bloodstream in the 1990s and was abandoned. An oncolytic herpes or adenovirus carrying the interleukin-12 gene under a drug-inducible promoter makes it only inside the tumour, keeping exposure local; trials include recurrent glioblastoma."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-oncolytic-regulated-il12/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/urothelial/> ;
  onco:technologies <https://onco.cc/technologies/oncolytic-virus/>, <https://onco.cc/technologies/cytokine-therapy/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:drugs <https://onco.cc/drugs/talimogene-laherparepvec/>, <https://onco.cc/drugs/vusolimogene-oderparepvec/>, <https://onco.cc/drugs/cretostimogene/>, <https://onco.cc/drugs/nadofaragene-firadenovec/> ;
  onco:companies <https://onco.cc/companies/replimune/>, <https://onco.cc/companies/cg-oncology/> ;
  onco:people <https://onco.cc/people/kevin-harrington/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-brain-delivery/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/> .