# OnCo record idea-bio2-radiotherapy-sting-fractionation (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-radiotherapy-sting-fractionation/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-radiotherapy-sting-fractionation" ;
  schema:name "Pick the radiation dose that switches the immune alarm on, not off"@en ;
  schema:description "Radiation can alert the immune system through the cGAS-STING pathway, but single doses above roughly 12 to 18 Gy switch on the enzyme TREX1, which destroys the alarm signal. Choosing fractionated schedules around 8 Gy times three for immune priming may add benefit at no extra cost."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-radiotherapy-sting-fractionation/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:related <https://onco.cc/pairings/radiation-plus-io/> ;
  onco:technologies <https://onco.cc/technologies/sbrt/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/flash-rt/> ;
  onco:pathways <https://onco.cc/pathways/cgas-sting/> ;
  onco:terms <https://onco.cc/terms/abscopal-effect/>, <https://onco.cc/terms/immunogenic-cell-death/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-surgery-radiation-innovation/>, <https://onco.cc/bottlenecks/b-immunotherapy-response/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/> .