# OnCo record idea-bio2-trem2-myeloid-reprogramming (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-trem2-myeloid-reprogramming/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-trem2-myeloid-reprogramming" ;
  schema:name "Reprogramme suppressive macrophages instead of trying to delete them"@en ;
  schema:description "Tumours fill with immune cells that protect them. Earlier drugs tried to remove those cells and failed. Newer ones aim to switch them to the attacking side."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-trem2-myeloid-reprogramming/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/glioblastoma/> ;
  onco:technologies <https://onco.cc/technologies/single-cell-spatial/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:terms <https://onco.cc/terms/cold-vs-hot/> ;
  onco:people <https://onco.cc/people/caetano-reis-e-sousa/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-immunotherapy-response/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/> .