# OnCo record idea-bio2-tumour-anchored-tgfbeta-trap (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-tumour-anchored-tgfbeta-trap/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-tumour-anchored-tgfbeta-trap" ;
  schema:name "Anchor a TGF-beta trap in the tumour stroma so it cannot act everywhere"@en ;
  schema:description "TGF-beta is a signal that keeps immune cells out of tumours, but blocking it throughout the body caused bleeding and heart toxicity and sank bintrafusp alfa. Tethering the blocker to tumour stroma with a FAP anchor, a collagen-binding domain or a protease-activated mask could give the benefit without the harm."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-tumour-anchored-tgfbeta-trap/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:cancers <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/masked-adc/>, <https://onco.cc/technologies/bispecific-antibody/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/pdl1/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/>, <https://onco.cc/key-papers/paper-pd-l1-urothelial-mol-cancer-ther-2015/>, <https://onco.cc/key-papers/paper-pd-l1-urothelial-trends-mol-med-2015/>, <https://onco.cc/key-papers/paper-pd-l1-urothelial-onco-targets-ther-2016/> .