# OnCo record idea-bio2-whole-genome-mrd-depth (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-whole-genome-mrd-depth/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-whole-genome-mrd-depth" ;
  schema:name "Push residual disease detection a hundredfold deeper with whole-genome methods"@en ;
  schema:description "Current blood tests for leftover cancer track a few dozen mutations and miss low-level disease. Whole-genome and error-corrected methods integrate signal across thousands of tumour-specific sites plus methylation and fragment features, reaching detection near one part per million in research settings; cost, turnaround and reproducibility are the barriers."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-whole-genome-mrd-depth/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2200075> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/fragmentomics/>, <https://onco.cc/technologies/methylation-profiling/>, <https://onco.cc/technologies/wes-wgs/> ;
  onco:companies <https://onco.cc/companies/foresight-diagnostics/>, <https://onco.cc/companies/delfi-diagnostics/>, <https://onco.cc/companies/personalis/> ;
  onco:terms <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/vaf/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dormancy-mrd/>, <https://onco.cc/bottlenecks/b-early-detection/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> .