# OnCo record idea-biomarker-quadruplet-gastric (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-biomarker-quadruplet-gastric/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-biomarker-quadruplet-gastric" ;
  schema:name "Biomarker-directed first-line quadruplets in gastric cancer"@en ;
  schema:description "Stomach cancer now has three add-on biomarkers (HER2, PD-L1, Claudin 18.2) that often overlap. Test whether combining two add-ons beats picking one."@en ;
  schema:url <https://onco.cc/ideas/idea-biomarker-quadruplet-gastric/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03504397>, <https://clinicaltrials.gov/study/NCT02872116> ;
  onco:cancers <https://onco.cc/cancers/gastric/> ;
  onco:targets <https://onco.cc/targets/cldn18-2/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/zolbetuximab/>, <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/zanidatamab/>, <https://onco.cc/drugs/tislelizumab/> ;
  onco:trials <https://onco.cc/trials/spotlight-glow/>, <https://onco.cc/trials/checkmate-649/>, <https://onco.cc/trials/herizon-gea-01/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-yarden-sliwkowski-erbb-network-nrmcb-2001/> .