# OnCo record idea-btc-ctdna-fgfr-resistance (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-btc-ctdna-fgfr-resistance/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-btc-ctdna-fgfr-resistance" ;
  schema:name "ctDNA-guided switching among FGFR inhibitors"@en ;
  schema:description "Track FGFR2 resistance mutations in blood and switch to the next-generation inhibitor that still covers them, before the scan shows progression."@en ;
  schema:url <https://onco.cc/ideas/idea-btc-ctdna-fgfr-resistance/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02924376>, <https://clinicaltrials.gov/study/NCT02052778> ;
  onco:cancers <https://onco.cc/cancers/cholangiocarcinoma/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/fgfr2/> ;
  onco:drugs <https://onco.cc/drugs/pemigatinib/>, <https://onco.cc/drugs/futibatinib/>, <https://onco.cc/drugs/tinengotinib/> ;
  onco:terms <https://onco.cc/terms/fgfr2-fusion/>, <https://onco.cc/terms/ctdna/> ;
  onco:trials <https://onco.cc/trials/fight-202/>, <https://onco.cc/trials/fight-302/>, <https://onco.cc/trials/first-308/>, <https://onco.cc/trials/nct05948475/>, <https://onco.cc/trials/nct07710885/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-fgfr2-cholangiocarcinoma-annu-rev-med-2023/>, <https://onco.cc/key-papers/paper-fgfr2-cholangiocarcinoma-cancers-basel-2026/>, <https://onco.cc/key-papers/paper-fgfr2-cholangiocarcinoma-int-j-mol-sci-2025/> .