# OnCo record idea-btk-degrader-frontline (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-btk-degrader-frontline/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-btk-degrader-frontline" ;
  schema:name "BTK degraders to pre-empt resistance in frontline CLL"@en ;
  schema:description "If destroying BTK works when every inhibitor has failed, using it first might stop resistance from ever emerging."@en ;
  schema:url <https://onco.cc/ideas/idea-btk-degrader-frontline/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.adi5798> ;
  onco:cancers <https://onco.cc/cancers/cll/> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/> ;
  onco:targets <https://onco.cc/targets/btk/>, <https://onco.cc/targets/bcl2/> ;
  onco:drugs <https://onco.cc/drugs/bgb-16673/>, <https://onco.cc/drugs/sonrotoclax/>, <https://onco.cc/drugs/acalabrutinib/>, <https://onco.cc/drugs/venetoclax/> ;
  onco:trials <https://onco.cc/trials/cadance-304/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-montoya-science/>, <https://onco.cc/key-papers/paper-acalabrutinib-cll-n-engl-j-med-2016/>, <https://onco.cc/key-papers/paper-bcl-2-cll-nat-rev-drug-discov-2017/>, <https://onco.cc/key-papers/paper-acalabrutinib-cll-j-clin-oncol-2021/> .