# OnCo record idea-cachexia-gdf15-prevention (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-cachexia-gdf15-prevention/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-cachexia-gdf15-prevention" ;
  schema:name "Treat cachexia before it starts"@en ;
  schema:description "Cachexia, the muscle wasting driven partly by the hormone GDF-15, kills cancer patients and stops chemotherapy being completed, and late muscle loss is largely irreversible. Ponsegromab, an anti-GDF-15 antibody, reversed weight loss in established cachexia in 2024; the next test is a phase 3 giving it from first-line chemotherapy in pancreatic cancer to prevent wasting rather than treat it."@en ;
  schema:url <https://onco.cc/ideas/idea-cachexia-gdf15-prevention/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2409515> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/gastric/> ;
  onco:technologies <https://onco.cc/technologies/exercise-oncology/> ;
  onco:institutions <https://onco.cc/institutions/fred-hutch/>, <https://onco.cc/institutions/cold-spring-harbor/> ;
  onco:pathways <https://onco.cc/pathways/cachexia-biology/>, <https://onco.cc/pathways/jak-stat/> .