# OnCo record idea-cdk4-selective-first-line (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-cdk4-selective-first-line/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-cdk4-selective-first-line" ;
  schema:name "CDK4-selective inhibitors as the new first-line backbone"@en ;
  schema:description "If a CDK4-only drug matches CDK4/6 inhibitors on efficacy with less neutropenia, continuous dosing and better adherence could translate into longer control."@en ;
  schema:url <https://onco.cc/ideas/idea-cdk4-selective-first-line/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT06105632> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:targets <https://onco.cc/targets/cdk4-6/> ;
  onco:drugs <https://onco.cc/drugs/atirmociclib/>, <https://onco.cc/drugs/palbociclib/>, <https://onco.cc/drugs/ribociclib/>, <https://onco.cc/drugs/abemaciclib/> ;
  onco:trials <https://onco.cc/trials/fourlight-1/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-paloma-2-n-engl-j-med-2016/>, <https://onco.cc/key-papers/paper-monaleesa-2-n-engl-j-med-2016/>, <https://onco.cc/key-papers/paper-palbociclib-breast-hr-positive-lancet-oncol-2015/> .