# OnCo record idea-chip-risk-modifiers (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-chip-risk-modifiers/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-chip-risk-modifiers" ;
  schema:name "Which patients' blood clones will become leukaemia after treatment?"@en ;
  schema:description "PARP inhibitors, platinum, and radioligand drugs can push pre-existing blood-cell clones toward leukaemia in a few patients. Predicting who could let us choose therapies more safely."@en ;
  schema:url <https://onco.cc/ideas/idea-chip-risk-modifiers/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1408617> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/prostate/> ;
  onco:technologies <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/radioligand-therapy/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/parp/>, <https://onco.cc/targets/tp53/> ;
  onco:institutions <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/clonal-haematopoiesis/>, <https://onco.cc/pathways/ddr/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/> .