# OnCo record idea-chronotherapy-immunotherapy (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-chronotherapy-immunotherapy/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-chronotherapy-immunotherapy" ;
  schema:name "Give immunotherapy in the morning"@en ;
  schema:description "Several studies found patients infused with checkpoint inhibitors earlier in the day lived longer. If a randomised trial confirms it, it is a free improvement available everywhere tomorrow."@en ;
  schema:url <https://onco.cc/ideas/idea-chronotherapy-immunotherapy/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S1470-2045(21)00546-5> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/melanoma/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pd1/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/gustave-roussy/> ;
  onco:pathways <https://onco.cc/pathways/circadian-control/>, <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:trials <https://onco.cc/trials/checkmate-227/>, <https://onco.cc/trials/checkmate-915/>, <https://onco.cc/trials/fianlimab-phase3-melanoma/>, <https://onco.cc/trials/keynote-042/>, <https://onco.cc/trials/relativity-098/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-qian-lancet-oncol/>, <https://onco.cc/key-papers/paper-topalian-anti-pd1-nejm-2012/>, <https://onco.cc/key-papers/paper-pd-1-nsclc-am-j-clin-oncol-2016/>, <https://onco.cc/key-papers/paper-kras-nsclc-cancer-discov-2018/> .