# OnCo record idea-cost-low-dose-abiraterone-food (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-cost-low-dose-abiraterone-food/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-cost-low-dose-abiraterone-food" ;
  schema:name "Prescribe a quarter dose of abiraterone with breakfast"@en ;
  schema:description "Taking 250 mg of abiraterone with a low-fat breakfast gives the same PSA response and testosterone suppression as the standard 1,000 mg fasting, because food increases absorption several-fold, so a quarter of the drug treats each man. The label still says fasting and no company promotes the food-effect dose, so adoption is patchy."@en ;
  schema:url <https://onco.cc/ideas/idea-cost-low-dose-abiraterone-food/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2017.76.4381> ;
  onco:cancers <https://onco.cc/cancers/prostate/> ;
  onco:sections <https://onco.cc/fronts/hormonal/> ;
  onco:technologies <https://onco.cc/technologies/androgen-deprivation/> ;
  onco:drugs <https://onco.cc/drugs/abiraterone/> ;
  onco:trials <https://onco.cc/trials/capitello-281/>, <https://onco.cc/trials/propel/>, <https://onco.cc/trials/nct05171816/>, <https://onco.cc/trials/nct01517802/>, <https://onco.cc/trials/nct03777982/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/>, <https://onco.cc/bottlenecks/b-drug-pricing/>, <https://onco.cc/bottlenecks/b-global-access/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-szmulewitz-j-clin-oncol/>, <https://onco.cc/key-papers/paper-abiraterone-acetate-prostate-n-engl-j-med-2013/>, <https://onco.cc/key-papers/paper-abiraterone-acetate-prostate-lancet-oncol-2015/>, <https://onco.cc/key-papers/paper-abiraterone-acetate-prostate-lancet-oncol-2012/> .