# OnCo record idea-crc-early-onset-cause-hunt (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-crc-early-onset-cause-hunt/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-crc-early-onset-cause-hunt" ;
  schema:name "Find out what is driving early-onset bowel cancer, starting with colibactin, before extending screening any further"@en ;
  schema:description "Bowel cancer in people under 50 is rising by 2 to 8 percent a year on both sides of the Atlantic and nobody knows why. The strongest lead is a toxin made by some gut bacteria whose damage signature is three times more common in young patients and is stamped on the colon early in life. If that is the cause, the fix is in childhood, not in a screening programme."@en ;
  schema:url <https://onco.cc/ideas/idea-crc-early-onset-cause-hunt/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/40267983>, <https://europepmc.org/article/MED/28376186>, <https://europepmc.org/article/MED/31097539> ;
  onco:tag "colorectal-evidence" ;
  onco:related <https://onco.cc/roadmaps/colorectal-roadmap/>, <https://onco.cc/roadmaps/prevention-roadmap/>, <https://onco.cc/institutions/iarc/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/early-onset-colorectal/> ;
  onco:sections <https://onco.cc/fronts/prevention/>, <https://onco.cc/fronts/early-detection/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/colorectal-screening/> ;
  onco:targets <https://onco.cc/targets/apc/> ;
  onco:pathways <https://onco.cc/pathways/microbiome-tumour/> ;
  onco:terms <https://onco.cc/terms/gut-microbiome-diversity/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-early-detection/>, <https://onco.cc/bottlenecks/b-prevention-adoption/>, <https://onco.cc/bottlenecks/b-translational-valley/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-diaz-gay-colibactin-geographic-age-mutational-processes-nature-2025/>, <https://onco.cc/key-papers/paper-siegel-colorectal-incidence-birth-cohort-jnci-2017/>, <https://onco.cc/key-papers/paper-vuik-early-onset-colorectal-europe-gut-2019/>, <https://onco.cc/key-papers/paper-hur-sugar-sweetened-beverages-early-onset-colorectal-gut-2021/> .