# OnCo record idea-crc-organ-preservation-randomised-in-pmmr-rectal (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-crc-organ-preservation-randomised-in-pmmr-rectal/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-crc-organ-preservation-randomised-in-pmmr-rectal" ;
  schema:name "Randomise organ preservation against surgery in mismatch repair-proficient rectal cancer, with bowel function as a co-primary endpoint"@en ;
  schema:description "Half of rectal cancer patients given all their chemotherapy and radiotherapy first can keep their rectum. Nobody has ever randomised that against having the operation, so the trade-off between avoiding a stoma and the risk of the cancer regrowing is still guesswork."@en ;
  schema:url <https://onco.cc/ideas/idea-crc-organ-preservation-randomised-in-pmmr-rectal/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/35483010>, <https://europepmc.org/article/MED/40293177>, <https://clinicaltrials.gov/study/NCT05610163> ;
  onco:tag "colorectal-evidence" ;
  onco:related <https://onco.cc/roadmaps/colorectal-roadmap/>, <https://onco.cc/roadmaps/surgery-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/rectal-cancer/> ;
  onco:sections <https://onco.cc/fronts/surgery/>, <https://onco.cc/fronts/radiation/> ;
  onco:technologies <https://onco.cc/terms/radiotherapy/>, <https://onco.cc/technologies/mri/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/technologies/robotic-surgery/> ;
  onco:drugs <https://onco.cc/drugs/folfox/>, <https://onco.cc/drugs/capox/>, <https://onco.cc/drugs/capecitabine/>, <https://onco.cc/drugs/dostarlimab/> ;
  onco:terms <https://onco.cc/terms/organ-preservation/>, <https://onco.cc/terms/clinical-complete-response/>, <https://onco.cc/terms/total-neoadjuvant-therapy/>, <https://onco.cc/terms/total-mesorectal-excision/> ;
  onco:trials <https://onco.cc/trials/opra/>, <https://onco.cc/trials/rapido/>, <https://onco.cc/trials/prodige-23/>, <https://onco.cc/trials/azur-1/> ;
  onco:people <https://onco.cc/people/julio-garcia-aguilar/>, <https://onco.cc/people/andrea-cercek/>, <https://onco.cc/people/angelita-habr-gama/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-surgery-radiation-innovation/>, <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-garcia-aguilar-opra-organ-preservation-jco-2022/>, <https://onco.cc/key-papers/paper-habr-gama-nonoperative-stage-0-rectal-ann-surg-2004/>, <https://onco.cc/key-papers/paper-cercek-nonoperative-management-mismatch-repair-deficient-tumours-nejm-2025/>, <https://onco.cc/key-papers/paper-bahadoer-rapido-short-course-radiotherapy-lancet-oncol-2021/> .