# OnCo record idea-ctdna-switch-generalised (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-ctdna-switch-generalised/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-ctdna-switch-generalised" ;
  schema:name "Molecular-progression switching beyond ESR1"@en ;
  schema:description "SERENA-6 showed you can act on a blood test before the scan changes. The same logic could apply to PIK3CA, AKT1, or HER2 mutations emerging on treatment."@en ;
  schema:url <https://onco.cc/ideas/idea-ctdna-switch-generalised/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04964934> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:drugs <https://onco.cc/drugs/camizestrant/>, <https://onco.cc/drugs/capivasertib/>, <https://onco.cc/drugs/inavolisib/> ;
  onco:terms <https://onco.cc/terms/esr1-mutation/>, <https://onco.cc/terms/ctdna/> ;
  onco:trials <https://onco.cc/trials/serena-6/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-capivasertib-breast-hr-positive-lancet-oncol-2022/>, <https://onco.cc/key-papers/paper-capivasertib-breast-hr-positive-breast-2022/>, <https://onco.cc/key-papers/paper-capivasertib-breast-hr-positive-drugs-2024/> .