# OnCo record idea-drugging-myc (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-drugging-myc/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-drugging-myc" ;
  schema:name "Can MYC be drugged directly, and will patients tolerate it?"@en ;
  schema:description "MYC drives half of all cancers but has no pocket for a drug and is needed by normal cells too. The first direct MYC blockers are in trials; the question is whether there is a therapeutic window."@en ;
  schema:url <https://onco.cc/ideas/idea-drugging-myc/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41591-024-02805-1> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/neuroblastoma/> ;
  onco:targets <https://onco.cc/targets/cd47/> ;
  onco:institutions <https://onco.cc/institutions/vall-dhebron/>, <https://onco.cc/institutions/ucsf/> ;
  onco:pathways <https://onco.cc/pathways/myc/> ;
  onco:trials <https://onco.cc/trials/nct05482893/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-garralda-nat-med/>, <https://onco.cc/key-papers/paper-cd47-pancreatic-pharmacol-res-2022/>, <https://onco.cc/key-papers/paper-cd47-neuroblastoma-curr-oncol-2024/> .