# OnCo record idea-dual-payload-first (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-dual-payload-first/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-dual-payload-first" ;
  schema:name "Dual-payload ADCs in first line to prevent resistance"@en ;
  schema:description "Rather than waiting for resistance to one payload and then switching, give two mechanisms from day one, as HIV therapy does."@en ;
  schema:url <https://onco.cc/ideas/idea-dual-payload-first/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41467-021-23793-7> ;
  onco:related <https://onco.cc/ideas/idea-payload-switching/> ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/dual-payload-adc/>, <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/site-specific-conjugation/> ;
  onco:targets <https://onco.cc/targets/trop2/>, <https://onco.cc/targets/her2/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-yarden-sliwkowski-erbb-network-nrmcb-2001/>, <https://onco.cc/key-papers/paper-yamazaki-nat-commun/> .