# OnCo record idea-ecdna-targeting (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-ecdna-targeting/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-ecdna-targeting" ;
  schema:name "Attack extrachromosomal DNA, the engine of oncogene amplification"@en ;
  schema:description "Aggressive glioblastomas, sarcomas and gastric cancers keep amplified cancer genes such as EGFR, MYC, MDM2 and CDK4 on free-floating DNA circles (ecDNA) whose copy number rises and falls quickly, letting the tumour dial resistance up and down. Cells carrying ecDNA depend on CHK1, giving a first drug target."@en ;
  schema:url <https://onco.cc/ideas/idea-ecdna-targeting/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature21356> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/gastric/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/cdk4-6/> ;
  onco:institutions <https://onco.cc/institutions/stanford/>, <https://onco.cc/institutions/cruk/> ;
  onco:pathways <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-turner-nature/>, <https://onco.cc/key-papers/paper-egfr-gastric-eur-j-cancer-2001/>, <https://onco.cc/key-papers/paper-egfr-glioblastoma-mol-oncol-2018/>, <https://onco.cc/key-papers/paper-egfr-glioblastoma-sci-signal-2009/> .