# OnCo record idea-ferroptosis-persisters (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-ferroptosis-persisters/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-ferroptosis-persisters" ;
  schema:name "Kill drug-tolerant persisters through ferroptosis"@en ;
  schema:description "The cells that survive targeted therapy change shape and become unusually dependent on an antioxidant enzyme, GPX4. Hitting them in that window might stop resistance before it evolves."@en ;
  schema:url <https://onco.cc/ideas/idea-ferroptosis-persisters/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature24297> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/melanoma/> ;
  onco:technologies <https://onco.cc/technologies/sbrt/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/alk/>, <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/> ;
  onco:institutions <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/stanford/> ;
  onco:pathways <https://onco.cc/pathways/ferroptosis-cell-death/>, <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-hangauer-nature/>, <https://onco.cc/key-papers/paper-flaura-nejm-2018/>, <https://onco.cc/key-papers/paper-egfr-nsclc-lancet-oncol-2012/>, <https://onco.cc/key-papers/paper-egfr-nsclc-n-engl-j-med-2010/> .