# OnCo record idea-fra-adc-sequencing-ovarian (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-fra-adc-sequencing-ovarian/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-fra-adc-sequencing-ovarian" ;
  schema:name "Sequence folate-receptor ADCs by payload class"@en ;
  schema:description "Three FRα ADCs carry different poisons (tubulin, hemiasterlin, topoisomerase). Use them in sequence rather than treating them as interchangeable."@en ;
  schema:url <https://onco.cc/ideas/idea-fra-adc-sequencing-ovarian/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04209855> ;
  onco:related <https://onco.cc/ideas/idea-payload-switching/> ;
  onco:cancers <https://onco.cc/cancers/ovarian/> ;
  onco:targets <https://onco.cc/targets/folr1/> ;
  onco:drugs <https://onco.cc/drugs/mirvetuximab-soravtansine/>, <https://onco.cc/drugs/rinatabart-sesutecan/>, <https://onco.cc/drugs/luveltamab-tazevibulin/> ;
  onco:terms <https://onco.cc/terms/adc-sequencing/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-mirasol-nejm-2023/>, <https://onco.cc/key-papers/paper-mirvetuximab-soravtansine-ovarian-j-clin-oncol-2023/>, <https://onco.cc/key-papers/paper-mirvetuximab-soravtansine-ovarian-ann-oncol-2021/> .