# OnCo record idea-fund-head-to-head-mandate (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-fund-head-to-head-mandate/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-fund-head-to-head-mandate" ;
  schema:name "Require head-to-head trials against the best in class for later entrants"@en ;
  schema:description "Once two drugs of a kind exist, a third should have to prove itself against the best of them, not against an outdated comparison, so patients and payers learn which is actually better."@en ;
  schema:url <https://onco.cc/ideas/idea-fund-head-to-head-mandate/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/d41573-022-00030-4> ;
  onco:related <https://onco.cc/ideas/idea-fund-benefit-indexed-exclusivity/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/datopotamab-deruxtecan/> ;
  onco:terms <https://onco.cc/terms/standard-of-care/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-incentive-misalignment/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-upadhaya-nat-rev-drug-discov/> .