# OnCo record idea-gbc-neoadjuvant-for-high-risk-incidental-cancer (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-gbc-neoadjuvant-for-high-risk-incidental-cancer/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-gbc-neoadjuvant-for-high-risk-incidental-cancer" ;
  schema:name "Chemotherapy before the second operation for high-risk incidental gallbladder cancer"@en ;
  schema:description "Gallbladder cancers found by chance often come back within six months of the second operation, usually far from the gallbladder, which suggests the disease was already in the bloodstream. Two randomised trials are testing chemotherapy first; one closed small, the other reports in 2028."@en ;
  schema:url <https://onco.cc/ideas/idea-gbc-neoadjuvant-for-high-risk-incidental-cancer/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/40064481>, <https://clinicaltrials.gov/study/NCT04559139>, <https://clinicaltrials.gov/study/NCT03673072> ;
  onco:tag "gallbladder-evidence" ;
  onco:cancers <https://onco.cc/cancers/gallbladder/> ;
  onco:drugs <https://onco.cc/drugs/gemcitabine-cisplatin/>, <https://onco.cc/drugs/durvalumab/> ;
  onco:institutions <https://onco.cc/institutions/ecog-acrin/>, <https://onco.cc/institutions/krankenhaus-nordwest/> ;
  onco:terms <https://onco.cc/cancers/incidental-gallbladder-cancer/>, <https://onco.cc/terms/neoadjuvant-adjuvant/>, <https://onco.cc/terms/radical-cholecystectomy/> ;
  onco:trials <https://onco.cc/trials/opt-in/>, <https://onco.cc/trials/gain-igbc/>, <https://onco.cc/trials/topaz-1/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-enrolment/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-varshney-neoadjuvant-incidental-gallbladder-cancer-systematic-review-ahbps-2025/>, <https://onco.cc/key-papers/paper-gain-trial-protocol-bmc-cancer-2020/> .