# OnCo record idea-gbc-reflex-her2-testing-advanced-biliary (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-gbc-reflex-her2-testing-advanced-biliary/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-gbc-reflex-her2-testing-advanced-biliary" ;
  schema:name "Reflex HER2 testing of every advanced gallbladder and extrahepatic biliary cancer"@en ;
  schema:description "Between one in eleven and one in five gallbladder cancers is HER2-positive and two HER2 drugs are now approved, but testing still happens only when someone asks. Making it automatic on every advanced biliary diagnosis, on resection tissue where it exists, would find the patients the trials were built for."@en ;
  schema:url <https://onco.cc/ideas/idea-gbc-reflex-her2-testing-advanced-biliary/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/42595189>, <https://europepmc.org/article/MED/37276871> ;
  onco:tag "gallbladder-evidence" ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/extrahepatic-cholangiocarcinoma/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/zanidatamab/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:terms <https://onco.cc/terms/her2-positive/>, <https://onco.cc/terms/ihc/>, <https://onco.cc/terms/fish/> ;
  onco:trials <https://onco.cc/trials/herizon-btc-01/>, <https://onco.cc/trials/herizon-btc-302/>, <https://onco.cc/trials/destiny-pantumor02/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-knowledge-diffusion/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-galdy-her2-biliary-tract-meta-analysis-cancer-metastasis-rev-2017/>, <https://onco.cc/key-papers/paper-angerilli-her2-gallbladder-extrahepatic-concordance-hum-pathol-2026/>, <https://onco.cc/key-papers/paper-harding-lancet-oncol/> .