# OnCo record idea-her2-adc-sequencing-payload (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-her2-adc-sequencing-payload/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-her2-adc-sequencing-payload" ;
  schema:name "Sequencing HER2 ADCs by payload after T-DXd"@en ;
  schema:description "When Enhertu stops working, the next ADC should probably carry a different kind of payload, such as the tubulin inhibitors in Kadcyla or ARX788, rather than another topoisomerase drug."@en ;
  schema:url <https://onco.cc/ideas/idea-her2-adc-sequencing-payload/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2115022>, <https://doi.org/10.1056/NEJMoa2203690> ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/trastuzumab-emtansine/>, <https://onco.cc/drugs/arx788/>, <https://onco.cc/drugs/disitamab-vedotin/> ;
  onco:terms <https://onco.cc/terms/adc-sequencing/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-katherine-nejm-2019/>, <https://onco.cc/key-papers/paper-trastuzumab-deruxtecan-breast-her2-positive-n-engl-j-med-2020/>, <https://onco.cc/key-papers/paper-kristine-lancet-oncol-2018/> .