# OnCo record idea-immune-exclusion-drivers (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-immune-exclusion-drivers/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-immune-exclusion-drivers" ;
  schema:name "What actually holds T cells at the tumour border?"@en ;
  schema:description "In immune-excluded tumours T cells reach the border but cannot get in, held back by fibroblasts, matrix, abnormal vessels, CXCL12 gradients or myeloid cells, and TGF-β drugs on their own have failed. If single-cell and spatial profiling can show which stromal programme dominates in each tumour, matching the drug (TGF-β, FAP, CXCR4 or VEGF) to it could let immunotherapy work."@en ;
  schema:url <https://onco.cc/ideas/idea-immune-exclusion-drivers/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature25501> ;
  onco:tag "mechanism", "open-question" ;
  onco:technologies <https://onco.cc/technologies/single-cell-spatial/>, <https://onco.cc/technologies/fapi-pet/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/pd1/> ;
  onco:institutions <https://onco.cc/institutions/gustave-roussy/>, <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/institut-curie/> ;
  onco:pathways <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:terms <https://onco.cc/terms/immune-exclusion/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-mariathasan-nature/> .