# OnCo record idea-immunotherapy-mss-crc (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-immunotherapy-mss-crc/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-immunotherapy-mss-crc" ;
  schema:name "Making microsatellite-stable colorectal cancer immunotherapy-responsive"@en ;
  schema:description "Ninety-five percent of bowel cancers ignore immunotherapy. Combinations that heat the tumour up (targeted drugs, radiation, new checkpoints) are the main hope."@en ;
  schema:url <https://onco.cc/ideas/idea-immunotherapy-mss-crc/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41591-024-03083-7> ;
  onco:related <https://onco.cc/roadmaps/colorectal-roadmap/>, <https://onco.cc/ideas/idea-crc-mss-immunotherapy-by-biomarker-not-by-line/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/kras-inhibitors/> ;
  onco:targets <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/kras/> ;
  onco:terms <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/msi/> ;
  onco:trials <https://onco.cc/trials/checkmate-8hw/>, <https://onco.cc/trials/codebreak-300/>, <https://onco.cc/trials/keynote-177/>, <https://onco.cc/trials/nct05855200/>, <https://onco.cc/trials/nct05890742/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-bullock-botensilimab-balstilimab-mss-colorectal-nat-med-2024/>, <https://onco.cc/key-papers/paper-topalian-anti-pd1-nejm-2012/>, <https://onco.cc/key-papers/paper-le-mmr-deficiency-pd1-nejm-2015/>, <https://onco.cc/key-papers/paper-ctla-4-colorectal-j-exp-clin-cancer-res-2019/> .