# OnCo record idea-lung-brain-metastasis-prevention-as-a-primary-endpoint (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-lung-brain-metastasis-prevention-as-a-primary-endpoint/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-lung-brain-metastasis-prevention-as-a-primary-endpoint" ;
  schema:name "Measure brain metastasis prevention as a primary endpoint, not as a secondary one"@en ;
  schema:description "Lung cancer spreads to the brain more than any other common cancer, and the newest drugs seem to stop it happening. Almost no trial is designed to prove that, so the claim stays a footnote."@en ;
  schema:url <https://onco.cc/ideas/idea-lung-brain-metastasis-prevention-as-a-primary-endpoint/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  onco:tag "lung-evidence" ;
  onco:related <https://onco.cc/ideas/idea-bio2-brain-met-prevention-trials/>, <https://onco.cc/ideas/idea-tr1-brain-mets-default-included/>, <https://onco.cc/ideas/idea-fund-brain-metastases-programme/>, <https://onco.cc/roadmaps/lung-cancer-evidence-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/alk-positive-nsclc/>, <https://onco.cc/cancers/egfr-mutant-nsclc/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/radiation/> ;
  onco:technologies <https://onco.cc/terms/stereotactic-radiosurgery/>, <https://onco.cc/terms/radiotherapy/> ;
  onco:terms <https://onco.cc/terms/brain-metastases/>, <https://onco.cc/technologies/prophylactic-cranial-irradiation/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-metastasis-biology/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-auperin-prophylactic-cranial-irradiation-sclc-nejm-1999/>, <https://onco.cc/key-papers/paper-shaw-crown-lorlatinib-crizotinib-nejm-2020/>, <https://onco.cc/key-papers/paper-peters-alex-alectinib-crizotinib-nejm-2017/>, <https://onco.cc/key-papers/paper-wu-alina-adjuvant-alectinib-nejm-2024/> .