# OnCo record idea-moon-closed-loop-adaptive-therapy (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-moon-closed-loop-adaptive-therapy/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-moon-closed-loop-adaptive-therapy" ;
  schema:name "Autonomous closed-loop adaptive therapy driven by blood tests and evolutionary models"@en ;
  schema:description "Rather than giving the same dose until the cancer grows, measure tumour DNA in blood every few weeks and let a validated algorithm raise, lower, pause or switch drugs to keep the cancer suppressed for longer."@en ;
  schema:url <https://onco.cc/ideas/idea-moon-closed-loop-adaptive-therapy/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1713137> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/prostate/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/> ;
  onco:institutions <https://onco.cc/institutions/moffitt/> ;
  onco:terms <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/resistance/> ;
  onco:trials <https://onco.cc/trials/adaura/>, <https://onco.cc/trials/flaura/>, <https://onco.cc/trials/flaura2/>, <https://onco.cc/trials/laura/>, <https://onco.cc/trials/nct06417814/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-dose-optimisation/>, <https://onco.cc/bottlenecks/b-ai-validation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-flaura-nejm-2018/>, <https://onco.cc/key-papers/paper-osimertinib-nsclc-n-engl-j-med-2017/>, <https://onco.cc/key-papers/paper-osimertinib-nsclc-n-engl-j-med-2020/> .