# OnCo record idea-moon-cold-to-hot-programme (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-moon-cold-to-hot-programme/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-moon-cold-to-hot-programme" ;
  schema:name "Make every cold tumour hot: a coordinated programme to reprogramme immune-excluded tumours"@en ;
  schema:description "Immunotherapy works in tumours that immune cells can enter and ignores those that shut them out. Systematically test ways to open up the shut-out tumours, measured with spatial maps."@en ;
  schema:url <https://onco.cc/ideas/idea-moon-cold-to-hot-programme/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/ovarian/> ;
  onco:technologies <https://onco.cc/technologies/single-cell-spatial/>, <https://onco.cc/technologies/sting-agonist/>, <https://onco.cc/technologies/oncolytic-virus/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/cd47/> ;
  onco:terms <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-immunotherapy-response/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/>, <https://onco.cc/key-papers/paper-cd47-pancreatic-pharmacol-res-2022/>, <https://onco.cc/key-papers/paper-cd47-colorectal-cancers-basel-2025/>, <https://onco.cc/key-papers/paper-cd47-colorectal-cancer-res-commun-2025/> .