# OnCo record idea-moon-engineered-immune-surveillance (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-moon-engineered-immune-surveillance/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-moon-engineered-immune-surveillance" ;
  schema:name "Engineered immune surveillance: long-lived programmed immune cells that patrol for early cancer"@en ;
  schema:description "For people at very high cancer risk, install a small population of engineered immune cells that live for years and destroy cells showing early cancer signals before a tumour forms."@en ;
  schema:url <https://onco.cc/ideas/idea-moon-engineered-immune-surveillance/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2200075> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/tcr-t/>, <https://onco.cc/technologies/car-nk-macrophage/>, <https://onco.cc/technologies/armored-car/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/brca/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dormancy-mrd/>, <https://onco.cc/bottlenecks/b-hereditary-risk/>, <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/> .