# OnCo record idea-moon-post-approval-dose-deescalation (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-moon-post-approval-dose-deescalation/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-moon-post-approval-dose-deescalation" ;
  schema:name "Randomised lower-dose trials for approved drugs with quality of life as the primary endpoint"@en ;
  schema:description "Many cancer drugs are approved at the highest dose patients could stand, not the best dose. Run trials that test lower doses on approved drugs and measure how patients feel."@en ;
  schema:url <https://onco.cc/ideas/idea-moon-post-approval-dose-deescalation/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.fda.gov/about-fda/oncology-center-excellence/project-optimus> ;
  onco:drugs <https://onco.cc/drugs/abemaciclib/>, <https://onco.cc/drugs/sotorasib/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-dose-optimisation/> .