# OnCo record idea-moon-synthetic-lethality-map-every-driver (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-moon-synthetic-lethality-map-every-driver/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-moon-synthetic-lethality-map-every-driver" ;
  schema:name "A synthetic lethality map for every cancer driver in every tissue context"@en ;
  schema:description "For each cancer-causing mutation, find every gene the cancer cell newly depends on, in every tissue, so that even undruggable drivers get druggable partners."@en ;
  schema:url <https://onco.cc/ideas/idea-moon-synthetic-lethality-map-every-driver/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://depmap.org/portal/> ;
  onco:technologies <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/organoids/>, <https://onco.cc/technologies/pdx-models/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/parp/> ;
  onco:terms <https://onco.cc/terms/synthetic-lethality/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/> .