# OnCo record idea-payload-switching (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-payload-switching/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-payload-switching" ;
  schema:name "Payload-class switching as the rule for ADC sequencing"@en ;
  schema:description "When one ADC fails, the next should carry a different kind of poison, not just aim at a different protein."@en ;
  schema:url <https://onco.cc/ideas/idea-payload-switching/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2028485>, <https://doi.org/10.1056/NEJMoa2115022> ;
  onco:related <https://onco.cc/pairings/adc-after-adc-caution/> ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/dual-payload-adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:terms <https://onco.cc/terms/adc-sequencing/>, <https://onco.cc/terms/efflux-pump/> .