# OnCo record idea-pdac-cachexia-trials-embedded-in-chemotherapy-trials (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-pdac-cachexia-trials-embedded-in-chemotherapy-trials/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-pdac-cachexia-trials-embedded-in-chemotherapy-trials" ;
  schema:name "Embed cachexia treatment in chemotherapy trials: weight, muscle and treatment delivery as co-primary endpoints"@en ;
  schema:description "Most people with pancreatic cancer lose muscle and weight in a way food alone cannot reverse, and that wasting is a common reason chemotherapy is cut or stopped. A 2024 trial showed an antibody against the hormone GDF-15 restored weight and activity in twelve weeks, a third of the patients having pancreatic cancer. The proposal is to test it inside the chemotherapy trials, not alongside them."@en ;
  schema:url <https://onco.cc/ideas/idea-pdac-cachexia-trials-embedded-in-chemotherapy-trials/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/39282907>, <https://europepmc.org/article/MED/21296615>, <https://clinicaltrials.gov/study/NCT05546476> ;
  onco:tag "pancreatic-evidence" ;
  onco:related <https://onco.cc/roadmaps/survivorship-roadmap/>, <https://onco.cc/ideas/idea-pdac-enzyme-replacement-prescribing-by-default/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/metastatic-pdac/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/>, <https://onco.cc/fronts/nutrition-lifestyle/> ;
  onco:drugs <https://onco.cc/drugs/ponsegromab/>, <https://onco.cc/drugs/folfirinox/>, <https://onco.cc/drugs/gemcitabine-nab-paclitaxel/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:terms <https://onco.cc/terms/performance-status/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-cachexia-supportive/>, <https://onco.cc/bottlenecks/b-aging-comorbidity/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-groarke-ponsegromab-cancer-cachexia-nejm-2024/>, <https://onco.cc/key-papers/paper-fearon-lancet-oncol/>, <https://onco.cc/key-papers/paper-roberts-pert-survival-pancreatic-cancer-pancreatology-2019/> .