# OnCo record idea-pdac-stromal-reprogramming-not-depletion (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-pdac-stromal-reprogramming-not-depletion/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-pdac-stromal-reprogramming-not-depletion" ;
  schema:name "Reprogramme the stroma rather than remove it: second-generation stromal trials with a stromal biomarker and a survival endpoint"@en ;
  schema:description "Pancreatic tumours are mostly scar tissue. The first attempt to dissolve it, an enzyme given with chemotherapy to nearly 500 patients, shrank more tumours but did not lengthen life, and mouse work showed that stripping out the scar-forming cells made cancers worse. The proposal is to test drugs that change what the stroma does rather than remove it, in trials measured on survival."@en ;
  schema:url <https://onco.cc/ideas/idea-pdac-stromal-reprogramming-not-depletion/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/32706635>, <https://europepmc.org/article/MED/24856586> ;
  onco:tag "pancreatic-evidence" ;
  onco:related <https://onco.cc/ideas/idea-fap-theranostics-pancancer/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/metastatic-pdac/> ;
  onco:technologies <https://onco.cc/technologies/fapi-pet/> ;
  onco:targets <https://onco.cc/targets/fap/> ;
  onco:pathways <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/emt/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/desmoplastic-stroma-rich/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-negative-results/>, <https://onco.cc/bottlenecks/b-preclinical-models/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-halo-301-pegvorhyaluronidase-jco-2020/>, <https://onco.cc/key-papers/paper-ozdemir-caf-depletion-accelerates-pancreatic-cancer-cancer-cell-2014/>, <https://onco.cc/key-papers/paper-moffitt-virtual-microdissection-subtypes-nat-genet-2015/> .