# OnCo record idea-prev-chemoprevention-master-protocol (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-prev-chemoprevention-master-protocol/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-prev-chemoprevention-master-protocol" ;
  schema:name "One master trial for cancer prevention drugs across many precancers"@en ;
  schema:description "Prevention drug trials run separately in each precancer and are slow. One master protocol with shared infrastructure across Barrett's oesophagus, oral leukoplakia, lung nodules and pancreatic cysts, using regression as an intermediate endpoint and adding or dropping arms adaptively, would test several drugs at once."@en ;
  schema:url <https://onco.cc/ideas/idea-prev-chemoprevention-master-protocol/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.3322/caac.21440> ;
  onco:sections <https://onco.cc/fronts/prevention/> ;
  onco:technologies <https://onco.cc/technologies/chemoprevention/> ;
  onco:institutions <https://onco.cc/institutions/nci/> ;
  onco:terms <https://onco.cc/terms/basket-umbrella-platform/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-prevention-adoption/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-islami-ca-cancer-j-clin/> .