# OnCo record idea-prev-mced-change-control-plan (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-prev-mced-change-control-plan/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-prev-mced-change-control-plan" ;
  schema:name "Pre-agreed update rules so an MCED test is not obsolete when its trial reads out"@en ;
  schema:description "A cancer blood test improves every year, but a ten-year trial tests the old version. Regulators and sponsors could agree in advance how updates are validated and carried into the result."@en ;
  schema:url <https://onco.cc/ideas/idea-prev-mced-change-control-plan/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.aay9040> ;
  onco:sections <https://onco.cc/fronts/early-detection/> ;
  onco:technologies <https://onco.cc/technologies/mced/>, <https://onco.cc/technologies/methylation-profiling/> ;
  onco:companies <https://onco.cc/companies/grail/> ;
  onco:trials <https://onco.cc/trials/nhs-galleri/>, <https://onco.cc/trials/pathfinder-2/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-early-detection/>, <https://onco.cc/bottlenecks/b-ai-validation/>, <https://onco.cc/bottlenecks/b-regulatory-fragmentation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-crosby-science/> .