# OnCo record idea-prev-vus-saturation-editing-consortium (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-prev-vus-saturation-editing-consortium/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-prev-vus-saturation-editing-consortium" ;
  schema:name "Test every possible mutation in every cancer gene so no result is 'uncertain'"@en ;
  schema:description "Genetic testing often returns a variant of uncertain significance that cannot be acted on, most often in people of non-European ancestry. Saturation genome editing has already classified nearly all BRCA1 single-nucleotide variants; a consortium doing the same for the roughly 30 actionable hereditary cancer genes would end most uncertain results."@en ;
  schema:url <https://onco.cc/ideas/idea-prev-vus-saturation-editing-consortium/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2017.73.6314> ;
  onco:related <https://onco.cc/collections/clinvar/> ;
  onco:sections <https://onco.cc/fronts/prevention/> ;
  onco:technologies <https://onco.cc/technologies/crispr-screens/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/tp53/> ;
  onco:terms <https://onco.cc/terms/vus/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-hereditary-risk/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-childers-j-clin-oncol/> .
