# OnCo record idea-pv-clone-directed-therapy (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-pv-clone-directed-therapy/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-pv-clone-directed-therapy" ;
  schema:name "Clearing the JAK2 clone in polycythaemia vera: interferon plus mutant-selective inhibitors as a route to treatment-free remission"@en ;
  schema:description "Today's PV drugs control blood counts but leave the mutant cells in place. Interferon is the one treatment that shrinks the clone, and the first JAK2 V617F-selective inhibitors have entered trials; combining the two could aim at molecular remission, the way imatinib did for CML."@en ;
  schema:url <https://onco.cc/ideas/idea-pv-clone-directed-therapy/> ;
  schema:dateModified "2026-09-16"^^xsd:date ;
  onco:tag "polycythaemia-vera", "mpn" ;
  onco:cancers <https://onco.cc/cancers/polycythaemia-vera/>, <https://onco.cc/cancers/myeloproliferative-neoplasms/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/jak2/> ;
  onco:drugs <https://onco.cc/drugs/ropeginterferon-alfa-2b/>, <https://onco.cc/drugs/ruxolitinib/> ;
  onco:trials <https://onco.cc/trials/proud-pv/>, <https://onco.cc/trials/majic-pv/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-jak2-polycythaemia-vera-lancet-2005/>, <https://onco.cc/key-papers/paper-jak2-polycythaemia-vera-nat-rev-cancer-2007/>, <https://onco.cc/key-papers/paper-jak2-myeloproliferative-neoplasms-leukemia-2010/> .