# OnCo record idea-reg-ai-process-control-cell-manufacturing (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-reg-ai-process-control-cell-manufacturing/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-reg-ai-process-control-cell-manufacturing" ;
  schema:name "Digital batch records and AI process control to halve cell therapy batch failures"@en ;
  schema:description "Autologous cell therapy batches fail more often than any other medicine because each patient's starting cells behave differently and the process runs without feedback. Inline sensors for metabolites, cell counts and cytokines, feeding models that adjust feeding and harvest timing in real time, could rescue batches that would otherwise be discarded."@en ;
  schema:url <https://onco.cc/ideas/idea-reg-ai-process-control-cell-manufacturing/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamaoncol.2018.0977> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/til-therapy/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/>, <https://onco.cc/bottlenecks/b-ai-validation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-hernandez-jama-oncol/> .